Journal article
Social Recognition Assay in the Rat
Current Protocols in Neuroscience, v 53(1), pp 8.5I.15-Unit 8.5I
Oct 2010
PMID: 20938925
Abstract
Abstract
Neuropsychiatric disorders encompass a broad patient population in a variety of disease states across all age groups and are often accompanied by deficits in short‐term/working memory. However, most preclinical models that allow for an assessment of cognitive enhancement do not provide robust behavioral readouts with a level of throughput sufficient to support modern drug discovery efforts. The rat social recognition assay presented in this unit is one exception that has been increasingly employed to test new chemical entities for enhancing cognitive activity. The test is simple in design and takes advantage of the spontaneous behavior of rats to investigate conspecifics. The protocol in this unit is designed to evaluate the effects of a test substance on the short‐term/working memory of adult male rats employing 30‐min or 2‐hr pretreatment times.
Curr. Protoc. Neurosci
. 53:8.51.1‐8.51.15. © 2010 by John Wiley & Sons, Inc.
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10 citations in Scopus
Details
- Title
- Social Recognition Assay in the Rat
- Creators
- Joanne R. Mathiasen - Cephalon West Chester PennsylvaniaAmy DiCamillo - Cephalon West Chester Pennsylvania
- Publication Details
- Current Protocols in Neuroscience, v 53(1), pp 8.5I.15-Unit 8.5I
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Scopus ID
- 2-s2.0-78449281260
- Other Identifier
- 991021900016104721