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Journal article
Social Stress Engages Neurochemically-Distinct Afferents to the Rat Locus Coeruleus Depending on Coping Strategy
eNeuro, v 2(6), pENEURO.0042-15.2015
Nov 2015
PMID: 26634226
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Stress increases vulnerability to psychiatric disorders, partly by affecting brain monoamine systems, such as the locus coeruleus (LC)-norepinephrine system. During stress, LC activity is coregulated by corticotropin-releasing factor (CRF) and endogenous opioids. This study identified neural circuitry that regulates LC activity of intruder rats during the resident-intruder model of social stress. LC afferents were retrogradely labeled with Fluorogold (FG) and rats were subjected to one or five daily exposures to an aggressive resident. Sections through the nucleus paragigantocellularis (PGi) and central amygdalar nucleus (CNA), major sources of enkephalin (ENK) and CRF LC afferents, respectively, were immunocytochemically processed to detect c-fos, FG, and CRF or ENK. In response to a single exposure, intruder rats assumed defeat with a relatively short latency (SL). LC neurons, PGI-ENK LC afferents, and CNA-CRF LC afferents were activated in these rats as indicated by increased c-fos expression. With repeated stress, rats exhibited either a SL or long latency (LL) to defeat and these strategies were associated with distinct patterns of neuronal activation. In SL rats, LC neurons were activated, as were CNA-CRF LC afferents but not PGI-ENK LC afferents. LL rats had an opposite pattern, maintaining activation of PGi-ENK LC afferents but not CNA-CRF LC afferents or LC neurons. Together, these results indicate that the establishment of different coping strategies to social stress is associated with changes in the circuitry that regulates activity of the brain norepinephrine system. This may underlie differential vulnerability to the consequences of social stress that characterize these different coping strategies.
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Details
- Title
- Social Stress Engages Neurochemically-Distinct Afferents to the Rat Locus Coeruleus Depending on Coping Strategy
- Creators
- Beverly A S Reyes - Drexel UniversityGerard Zitnik - Children's Hospital of PhiladelphiaCelia Foster - Drexel UniversityElisabeth J Van Bockstaele - Drexel UniversityRita J Valentino - Children's Hospital of Philadelphia
- Publication Details
- eNeuro, v 2(6), pENEURO.0042-15.2015
- Publisher
- Society for Neuroscience
- Grant note
- T32 MH14654 / NIMH NIH HHS R01 DA009082 / NIDA NIH HHS MH093981 / NIMH NIH HHS DA09082 / NIDA NIH HHS R01 MH093981 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000218571500002
- Scopus ID
- 2-s2.0-85013217149
- Other Identifier
- 991019185110104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences