Journal article
Socio-demographic predictors of prepulse inhibition: A prospective study in children and adolescents from Mexico City
Biological psychology, v 145, pp 8-16
Jul 2019
PMID: 30940478
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•In children, Prepulse inhibition (PPI) deficits are associated with neurodevelopmental disorders.•We used a data-driven prediction model to identify six important predictors of PPI.•We found that typical predictors of neurodevelopmental disorders also predict PPI.•Our findings underscore the potential utility of PPI as a biological marker of neurodevelopmental disorders.
Prepulse inhibition (PPI) is a sensorimotor gating mechanism that reduces interfering influences to the neural processing of incoming stimuli, and is associated with several neurodevelopmental disorders. To date, research on PPI and neurodevelopmental disorders has primarily been in cross-sectional, clinical settings. In this prospective, epidemiologic study, we used a data-driven prediction model to identify socio-demographic predictors of PPI in children and adolescents from Mexico City to inform future etiologic studies evaluating PPI. We conducted variable selection and validation using a modified version of the multiple imputation random lasso (MIRL) variable selection algorithm. MIRL identified six predictors of PPI at a stimulus onset asynchrony of 120 ms or 240 ms. Of those six predictors, maternal education, birthweight, and total breastfeeding months were highlighted as previously unstudied variables associated with enhanced PPI. Our findings highlight the potential value of PPI as an adjunct screening tool for identifying children at risk for neurodevelopmental disorders and underscore the relevance for validation research on this topic.
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Details
- Title
- Socio-demographic predictors of prepulse inhibition: A prospective study in children and adolescents from Mexico City
- Creators
- Kalé Z. Kponee-Shovein - Harvard UniversityRachel Grashow - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USABrent A. Coull - Harvard UniversityMartha M. Téllez-Rojo - Center for Nutrition and Health Research, National Institute of Public Health, Mexico.Lourdes Schnaas - Instituto Nacional de PerinatologíaMaria del Carmen Hernández-Chávez - Instituto Nacional de PerinatologíaBrisa Sánchez - University of MichiganKaren Peterson - University of MichiganHoward Hu - University of WashingtonMauricio Hernandez-Avila - Center for Nutrition and Health Research, National Institute of Public Health, Mexico.Marc G. Weisskopf - Harvard University
- Publication Details
- Biological psychology, v 145, pp 8-16
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000470090100002
- Scopus ID
- 2-s2.0-85064155799
- Other Identifier
- 991020100208204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Behavioral Sciences
- Psychology
- Psychology, Biological
- Psychology, Experimental