Journal article
Sodium Currents in Neurons From the Rostroventrolateral Medulla of the Rat
Journal of neurophysiology, v 90(3), pp 1635-1642
Sep 2003
PMID: 12761275
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rapidly inactivating and persistent sodium currents have been characterized in acutely dissociated neurons from the area of rostroventrolateral medulla that included the pre-Bötzinger Complex. As demonstrated in many studies in vitro, this area can generate endogenous rhythmic bursting activity. Experiments were performed on neonate and young rats (P1-15). Neurons were investigated using the whole cell voltage-clamp technique. Standard activation and inactivation protocols were used to characterize the steady-state and kinetic properties of the rapidly inactivating sodium current. Slow depolarizing ramp protocols were used to characterize the noninactivating sodium current. The “window” component of the rapidly inactivating sodium current was calculated using mathematical modeling. The persistent sodium current was revealed by subtraction of the window current from the total noninactivating sodium current. Our results provide evidence of the presence of persistent sodium currents in neurons of the rat rostroventrolateral medulla and determine voltage-gated characteristics of activation and inactivation of rapidly inactivating and persistent sodium channels in these neurons.
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Details
- Title
- Sodium Currents in Neurons From the Rostroventrolateral Medulla of the Rat
- Creators
- Ilya A Rybak - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104Krzysztof Ptak - Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-3008Natalia A Shevtsova - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104Donald R McCrimmon - Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611-3008
- Publication Details
- Journal of neurophysiology, v 90(3), pp 1635-1642
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000185217700026
- Scopus ID
- 2-s2.0-0042350819
- Other Identifier
- 991014878440004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Physiology