Journal article - Review
Sodium bicarbonate in cardiac arrest: A reappraisal
American Journal of Emergency Medicine, v 14(2), pp 192-206
01 Mar 1996
PMID: 8924147
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The routine use of sodium bicarbonate in patients with cardiac arrest has been discouraged, without the benefit of outcome evaluation. Current recommendations include an elaborate stratification of circumstances in which bicarbonate is to be used. The physiological and clinical aspects of bicarbonate administration during cardiopulmonary resuscitation in animal and human studies were reviewed. The onset of significant acidemia or alkalemia is associated with adverse system-specific effects. The administration of bicarbonate may mitigate the adverse physiological effects of acidemia, improve response to exogenously administered vasopressor agents, or simply increase venous return due to an osmolar effect, resulting in increased coronary perfusion pressure. Likewise, bicarbonate may have adverse effects in each of these areas. The preponderance of evidence suggests that bicarbonate is not detrimental and may be helpful to outcome from cardiac arrest. An objective reappraisal of the empirical use of bicarbonate or other buffer agents in the appropriate “therapeutic window” for cardiac arrest patients may be warranted.
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Details
- Title
- Sodium bicarbonate in cardiac arrest: A reappraisal
- Creators
- Rade B Vukmir - University of Pittsburgh Medical CenterNicholas Bircher - University of Pittsburgh Medical CenterPeter Safar - University of Pittsburgh Medical Center
- Publication Details
- American Journal of Emergency Medicine, v 14(2), pp 192-206
- Publisher
- Elsevier
- Number of pages
- 15
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1996UA96500018
- Scopus ID
- 2-s2.0-0029877748
- Other Identifier
- 991021903243204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Emergency Medicine