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Journal article
Soft, Multifunctional MXene-Coated Fiber Microelectrodes for Biointerfacing
ACS nano, v 18(34), pp 23217-23231
14 Aug 2024
PMID: 39141004
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Flexible fiber-based microelectrodes allow safe and chronic investigation and modulation of electrically active cells and tissues. Compared to planar electrodes, they enhance targeting precision while minimizing side effects from the device-tissue mechanical mismatch. However, the current manufacturing methods face scalability, reproducibility, and handling challenges, hindering large-scale deployment. Furthermore, only a few designs can record electrical and biochemical signals necessary for understanding and interacting with complex biological systems. In this study, we present a method that utilizes the electrical conductivity and easy processability of MXenes, a diverse family of two-dimensional nanomaterials, to apply a thin layer of MXene coating continuously to commercial nylon filaments (30–300 μm in diameter) at a rapid speed (up to 15 mm/s), achieving a linear resistance below 10 Ω/cm. The MXene-coated filaments are then batch-processed into free-standing fiber microelectrodes with excellent flexibility, durability, and consistent performance even when knotted. We demonstrate the electrochemical properties of these fiber electrodes and their hydrogen peroxide (H2O2) sensing capability and showcase their applications in vivo (rodent) and ex vivo (bladder tissue). This scalable process fabricates high-performance microfiber electrodes that can be easily customized and deployed in diverse bioelectronic monitoring and stimulation studies, contributing to a deeper understanding of health and disease.
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Details
- Title
- Soft, Multifunctional MXene-Coated Fiber Microelectrodes for Biointerfacing
- Creators
- Lingyi Bi - Drexel University, A.J. Drexel Nanomaterials InstituteRaghav Garg - University of PennsylvaniaNatalia Noriega - University of BrightonRuocun John Wang - Drexel University, Materials Science and EngineeringHyunho Kim - Drexel University, Materials Science and EngineeringKseniia Vorotilo - Drexel UniversityJustin C Burrell - Department of Oral and Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, United StatesChristopher E Shuck - Department of Materials Science and Engineering and A. J. Drexel Nanomaterials Institute, Drexel University, Philadelphia, Pennsylvania 19104, United StatesFlavia Vitale - University of PennsylvaniaBhavik Anil Patel - University of BrightonYury Gogotsi (Corresponding Author) - Drexel University, Materials Science and Engineering
- Publication Details
- ACS nano, v 18(34), pp 23217-23231
- Publisher
- ACS Publications
- Number of pages
- 15
- Grant note
- This study received support from NSF grant DMR-2041050 for MXene development and NIH grant R01NS121219 for biomedical work. SEM and XRD analyses were conducted at the Materials Characterization Core (RRID: SCR_022684) at Drexel University. The authors express appreciation to Dr. Kacy Cullen at the University of Pennsylvania for providing electrophysiological stimulation and recording equipment, Dr. Stepan Vorotilo at Drexel University for creating schematics of fiber structures and dip coating setup, as well as Dr. Mikhail Shekhirev and Jeffrey Busa for support in MXene synthesis. This research was partially conducted at the Singh Center for Nanotechnology, a part of the National Nanotechnology Coordinated Infrastructure Program, funded by the National Science Foundation grant NNCI-2025608. J.B. received support from NIDCR (NIH) T90-DE030854. T90 DE030854 / NIDCR NIH HHS R01 NS121219 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; A.J. Drexel Nanomaterials Institute
- Web of Science ID
- WOS:001291793000001
- Scopus ID
- 2-s2.0-85201386557
- Other Identifier
- 991021897114404721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology