Journal article
Solid freeform fabrication of polycaprolactone/hydroxyapatite tissue scaffolds
Journal of manufacturing science and engineering, v 130(2), pp 0210181-0210186
01 Apr 2008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bone tissue engineering is an emerging field providing viable substitutes for bone regeneration. Freeform fabrication provides an effective process tool to manufacture scaffolds with complex shapes and designed properties. We developed a novel precision extruding deposition (PED) technique to fabricate composite polycaprolactone/hydroxyapatite (PCL/HA) scaffolds. 25% concentration by weight of HA was used to reinforce 3D scaffolds. Two groups of scaffolds having 60% and 70% porosities and with pore sizes of 450 mu m and 750 mu m respectively, were evaluated for their morphology and compressive properties using scanning electron microscopy and the mechanical testing. In vitro cell scaffold interaction study was carried out using primary fetal bovine osteoblasts. The cell proliferation and differentiation were evaluated by Alamar Blue assay and alkaline phosphatase activity. Our results suggested that compressive modulus of PCL/HA scaffold was 84 Mpa for 60% porous scaffolds and was 76 MPa for 70% porous scaffolds. The osteoblasts were able to migrate and proliferate for the cultured time over the scaffolds. Our study demonstrated the viability of the PED process to fabricate PCL scaffolds having necessary mechanical property, structural integrity, controlled pore size, and pore interconnectivity desired for bone tissue engineering.
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Details
- Title
- Solid freeform fabrication of polycaprolactone/hydroxyapatite tissue scaffolds
- Creators
- L. Shor - Drexel UniversityS. Gueceri - Drexel Univ, Lab Comp Aided Tissue Engn, Dept Mech Engn & Mech, Philadelphia, PA 19104 USAM. Gandhi - Drexel UniversityX. Wen - Clemson UniversityW. Sun - Drexel University
- Publication Details
- Journal of manufacturing science and engineering, v 130(2), pp 0210181-0210186
- Publisher
- Asme
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000255846300019
- Scopus ID
- 2-s2.0-47049121091
- Other Identifier
- 991019167608604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Manufacturing
- Engineering, Mechanical