Journal article
Solid-phase synthesis, characterization, and cellular activities of collagen-model nanodiamond-peptide conjugates
Biopolymers, v 104(3), pp 186-195
May 2015
PMID: 25753561
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nanodiamonds (NDs) have received considerable attention as potential drug delivery vehicles. NDs are small (∼5 nm diameter), can be surface modified in a controllable fashion with a variety of functional groups, and have little observed toxicity in vitro and in vivo. However, most biomedical applications of NDs utilize surface adsorption of biomolecules, as opposed to covalent attachment. Covalent modification provides reliable and reproducible ND-biomolecule ratios, and alleviates concerns over biomolecule desorption prior to delivery. The present study has outlined methods for the efficient solid-phase conjugation of ND to peptides and characterization of ND-peptide conjugates. Utilizing collagen-derived peptides, the ND was found to support or even enhance the cell adhesion and viability activities of the conjugated sequence. Thus, NDs can be incorporated into peptides and proteins in a selective manner, where the presence of the ND could potentially enhance the in vivo activities of the biomolecule it is attached to.
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Details
- Title
- Solid-phase synthesis, characterization, and cellular activities of collagen-model nanodiamond-peptide conjugates
- Creators
- Anna M Knapinska - Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, 34987Dorota Tokmina-Roszyk - Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, 34987Sabrina Amar - Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, 34987Michal Tokmina-Roszyk - Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, 34987Vadym N Mochalin - Department of Materials Science and Engineering and A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA, 19104Yury Gogotsi - Department of Materials Science and Engineering and A.J. Drexel Nanotechnology Institute, Drexel University, Philadelphia, PA, 19104Patrick Cosme - Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL, 33458Andrew C Terentis - Department of Chemistry and Biochemistry, Florida Atlantic University, Jupiter, FL, 33458Gregg B Fields - Department of Chemistry, The Scripps Research Institute/Scripps Florida, Jupiter, FL, 33458
- Publication Details
- Biopolymers, v 104(3), pp 186-195
- Publisher
- Wiley; United States
- Grant note
- R01 CA098799 / NCI NIH HHS CA098799 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000358880400007
- Scopus ID
- 2-s2.0-85015823696
- Other Identifier
- 991014878143904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics