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Solitary Skeletal Muscle Metastasis as First Site of Recurrence of Cervical Cancer: A Case Report
Journal article   Open access   Peer reviewed

Solitary Skeletal Muscle Metastasis as First Site of Recurrence of Cervical Cancer: A Case Report

Indumathy Varadarajan, Aparna Basu, Sherri Besmer, Jaganmohan Poli, Scott Richard and Michael Styler
Case reports in oncology, v 10(2), pp 694-698
04 Aug 2017
DOI: https://doi.org/10.1159/000478976
PMID: 28878652
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1159/000478976View
Published, Version of Record (VoR)CC BY-NC V4.0,  Open

Abstract

Case Report Cervical cancer Gynecological cancer Human papillomavirus Metastasis Musculoskeletal metastasis Solitary metastasis
Cervical cancer is the fourth most common cancer in women worldwide, with a large majority of prevalence (85%) in developing countries. As of 2012, it accounts for 7.5% of all female cancer deaths. Despite its high prevalence, skeletal muscle metastasis from cervical cancer is extremely uncommon. In our extensive literature search, we were able to find only 8 cases where skeletal muscle metastasis was the only site of recurrence. We report a case of a 52-year-old African-American woman with a past medical history of cervical cancer (stage IIIB) who presented with pain and swelling in her left upper arm over the preceding 2 months. MRI of the left upper arm showed a solid well-circumscribed mass measuring 7.0 × 2.8 × 2.5 cm, deep to the biceps. Biopsy of the mass revealed a metastatic squamous cell carcinoma that was p16-positive. PET scan showed that the lesion was the sole site of metastasis. She received local radiation with concurrent chemotherapy. Follow-up MRI 6 months after the completion of therapy showed resolution of the mass. She has remained disease-free for the last 24 months as evidenced by a PET/CT scan in May 2016. In this case report, we discuss the role of imaging and pathology in the diagnosis of a solitary metastatic lesion. This case also emphasizes the importance of a close follow-up which aids in early intervention, increasing overall survival.

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6 citations in Web of Science
5 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Oncology
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