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Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic Ketoacidosis
Journal article   Open access   Peer reviewed

Soluble Receptor for Glycation End-products Concentration Increases Following the Treatment of Severe Diabetic Ketoacidosis

William H. Hoffman, Takaki Ishikawa, James Blum, Naoto Tani, Tomoya Ikeda and Carol M. Artlett
Journal of clinical research in pediatric endocrinology, v 12(2), pp 160-167
03 Jun 2020
DOI: https://doi.org/10.4274/jcrpe.galenos.2019.2019.0076
PMID: 31514489
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.4274/jcrpe.galenos.2019.2019.0076View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open

Abstract

Adolescent Child Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetic Ketoacidosis - blood Diabetic Ketoacidosis - drug therapy Diabetic Ketoacidosis - etiology Female Glycation End Products, Advanced - blood Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Inflammation - blood Insulin - administration & dosage Lactic Acid - blood Longitudinal Studies Male Myocarditis - blood Receptor for Advanced Glycation End Products - blood Severity of Illness Index Treatment Outcome
To determine the time relationships of soluble receptor for glycation end-products (sRAGE), [a decoy of the advanced glycation end-products (AGE)-RAGE axis] and D-lactate, (a metabolite of methylglyoxal) in the inflammatory response to diabetic ketoacidosis (DKA). Sixteen children and adolescents with type 1 diabetes (T1D) had blood samples obtained, 6-12 hours into treatment, at three weeks and three months post start of treatment. sRAGE and D-lactate concentrations at three months were considered baseline. Expression of RAGE was investigated in the myocardium of a newly diagnosed and untreated young person with fatal T1D/DKA. sRAGE 6-12 hours after the start of treatment was 39% lower than the values at two weeks (p=0.0036) and at three months (p=0.0023) post treatment. D-lactate was higher during treatment than at three weeks (p=0.04) and at three months (p=0.035). sRAGE concentration was decreased during treatment, compared to concentrations at two weeks and three months after treatment. The increased D-lactate during treatment was in keeping with the known increase in dicarbonyls at this time. The finding of RAGE expression in a young myocardium prior to DKA treatment suggested cardiovascular inflammation pre-treatment and at a young age.

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5 citations in Web of Science
5 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Endocrinology & Metabolism
Pediatrics
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