Journal article
Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease
Journal of neuroimmunology, v 319, pp 19-27
15 Jun 2018
PMID: 29685286
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Alzheimer's disease (AD) has been genetically and pathologically associated with neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor involved in innate immunity. TREM2 rare protein coding genetic variants have been linked to AD. A soluble TREM2 (sTREM2) cleavage product is elevated in AD. It is unclear whether there is a relationship between elevated sTREM2 and markers of inflammation. The hypothesis of this investigation was that central and peripheral inflammation play a role in sTREM2 levels in AD. A consistent association of peripheral or central markers of inflammation and CSF sTREM2 levels was not found, suggesting a limited impact of general inflammation on sTREM2 levels. An association between peripheral sTREM2 levels and CSF sTREM2, as well as an association between CSF sTREM2 and a marker of blood brain barrier integrity, was observed in AD, suggesting a potential role of peripheral TREM2 in central TREM2 biology.
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Details
- Title
- Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease
- Creators
- L. M. Bekris - Cleveland ClinicM. Khrestian - Cleveland ClinicE. Dyne - Kent State UniversityY. Shao - Cleveland ClinicJ. A. Pillai - Lou Ruvo Brain InstituteS. M. Rao - Lou Ruvo Brain InstituteS. M. Bemiller - Indiana University – Purdue University IndianapolisB. Lamb - Indiana University – Purdue University IndianapolisH. H. Fernandez - Cleveland ClinicJ. B. Leverenz - Lou Ruvo Brain Institute
- Publication Details
- Journal of neuroimmunology, v 319, pp 19-27
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- AG034214; AG051495; AG055685; AG022304 / National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Jane and Lee Seidman Fund National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K99AG034214 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000433016400004
- Scopus ID
- 2-s2.0-85044440374
- Other Identifier
- 991021957275104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences