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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Soluble receptor for advanced glycation end products and the risk for incident heart failure: The Atherosclerosis Risk in Communities Study
The American heart journal, v 170(5), pp 961-967
01 Nov 2015
PMID: 26542505
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Experimental studies in animals suggest that circulating soluble receptor for advanced glycation end products (sRAGE) decrease oxidative stress, inflammation, and fibrosis. The association between sRAGE and incident heart failure has not been systematically examined in a prospective study.
We conducted a prospective analysis of a subsample of 1,086 participants from the Atherosclerosis Risk in Communities Study who attended visit 2 (1990-1992) without a history of coronary heart disease, stroke, or heart failure and with measured plasma sRAGE levels. Incident heart failure was defined as death from heart failure or hospitalization due to heart failure during a median of 20 years of follow-up.
In this sample of a community-based population (mean age 63 years, 60% women, 78% white), there were 126 incident cases of heart failure. Lower levels of sRAGE were significantly associated with an increased risk of heart failure; the adjusted hazard ratios (95% CIs) of heart failure were 1.0 (reference), 1.81 (0.94-3.49), 1.57 (0.80-3.08), and 3.37 (1.75-6.50), for fourth, third, second, and first quartiles, respectively (P for trend = .001). We did not observe significant interactions by diabetes status or by race or obesity status.
Lower circulating levels of sRAGE are independently associated with the development of heart failure in a community-based population. Our results add to the growing evidence that sRAGE is a valuable predictor of cardiovascular disease.
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Details
- Title
- Soluble receptor for advanced glycation end products and the risk for incident heart failure: The Atherosclerosis Risk in Communities Study
- Creators
- Mariana Lazo - Johns Hopkins MedicineMarc K Halushka - Johns Hopkins MedicineLu Shen - Bloomberg (United States)Nisa Maruthur - Johns Hopkins MedicineCasey M Rebholz - Bloomberg (United States)Andreea M Rawlings - Bloomberg (United States)Ron C Hoogeveen - Baylor College of MedicineTina E Brinkley - Wake Forest UniversityChristie M Ballantyne - Baylor College of MedicineBrad C Astor - University of Wisconsin–MadisonElizabeth Selvin - Johns Hopkins University
- Publication Details
- The American heart journal, v 170(5), pp 961-967
- Publisher
- Elsevier
- Grant note
- HHSN268201100006C / PHS HHS HHSN268201100010C / NHLBI NIH HHS HHSN268201100005C / NHLBI NIH HHS HHSN268201100007C / NHLBI NIH HHS HHSN268201100012C / PHS HHS HHSN268201100008C / NHLBI NIH HHS HHSN268201100008C / PHS HHS HHSN268201100012C / NHLBI NIH HHS R01-DK076770 / NIDDK NIH HHS HHSN268201100007C / PHS HHS HHSN268201100008I / NHLBI NIH HHS HHSN268201100005G / NHLBI NIH HHS HHSN268201100009C / PHS HHS HHSN268201100005I / NHLBI NIH HHS HHSN268201100011C / PHS HHS HHSN268201100010C / PHS HHS HHSN268201100006C / NHLBI NIH HHS R01 DK076770 / NIDDK NIH HHS HHSN268201100005C / PHS HHS HHSN268201100009C / NHLBI NIH HHS HHSN268201100011C / NHLBI NIH HHS HHSN268201100011I / NHLBI NIH HHS HHSN268201100007I / NHLBI NIH HHS HHSN268201100009I / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000364434600017
- Scopus ID
- 2-s2.0-84954270822
- Other Identifier
- 991020550347304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems