Journal article
Somatic Cell Encystment Promotes Abscission in Germline Stem Cells following a Regulated Block in Cytokinesis
Developmental cell, v 34(2), pp 192-205
27 Jul 2015
PMID: 26143993
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In many tissues, the stem cell niche must coordinate behavior across multiple stem cell lineages. How this is achieved is largely unknown. We have identified delayed completion of cytokinesis in germline stem cells (GSCs) as a mechanism that regulates the production of stem cell daughters in the Drosophila testis. Through live imaging, we show that a secondary F-actin ring is formed through regulation of Cofilin activity to block cytokinesis progress after contractile ring disassembly. The duration of this block is controlled by Aurora B kinase. Additionally, we have identified a requirement for somatic cell encystment of the germline in promoting GSC abscission. We suggest that this non-autonomous role promotes coordination between stem cell lineages. These findings reveal the mechanisms by which cytokinesis is inhibited and reinitiated in GSCs and why such complex regulation exists within the stem cell niche.
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Details
- Title
- Somatic Cell Encystment Promotes Abscission in Germline Stem Cells following a Regulated Block in Cytokinesis
- Creators
- Kari F. Lenhart - University of PennsylvaniaStephen DiNardo - University of Pennsylvania
- Publication Details
- Developmental cell, v 34(2), pp 192-205
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- PF-13-029-01-DDC / ACS Post-doctoral Fellowship R01GM060804 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000358599400010
- Scopus ID
- 2-s2.0-84938215272
- Other Identifier
- 991020099834004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Developmental Biology