Journal article
Some factors affecting the transient cylindrical diffusion of oxygen in an artificial capillary model and comparisons with in vivo data
Microvascular research, v 4(1), pp 13-25
1972
PMID: 4556515
Abstract
In vivo studies of cat gastrocnemius and soleus muscles in which we recorded
PO
2 disappearance curves following arterial occlusion initiated these studies.
2
2
We wish to thank Dr. Roger A. Ganfield, Ph.D., for his invaluable help in the early stages of these studies. Our thanks to Dr. W. J. Whalen, Ph.D., for encouragement and guidance in our work and to Sister Helen Kuhn for assistance in obtaining some of the
in vivo data.
Each muscle demonstrated a characteristic curve and explanations based on myoglobin content and oxygen consumption rate were indicated. The following studies were performed in an attempt to resolve our inquiries.
Oxygen consumption rate and Krogh's diffusion coefficient were varied independently in a silastic artificial vessel-tissue chamber in which yeast was the metabolizing media. After establishing a flow rate which assured negligible longitudinal gradients, steady-state
PO
2 profiles were taken using 200 μ radial intervals. At each level the disappearance curve of
PO
2 was also measured during stopped flow. The steady-state values agreed closely with values calculated from the steady-state cylindrical diffusion equation. The decay curves were studied to determine the effects of
V
̇
O
2
, DS, and
r on the time coefficient in order to obtain a closed form approximate solution to the transient cylindrical diffusion equation for oxygen in a metabolizing media. While no one equation was found which contained these parameters and was specific to the curves, three relationships were determined empirically to define three distinct sections of the curves. Future experiments in which all parameters are measured will allow application of the equation to
in vivo studies.
Metrics
Details
- Title
- Some factors affecting the transient cylindrical diffusion of oxygen in an artificial capillary model and comparisons with in vivo data
- Creators
- Claire Ann Thuning - St. Vincent Charity HospitalDonald G. Buerk - St. Vincent Charity Hospital
- Publication Details
- Microvascular research, v 4(1), pp 13-25
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:A1972L607400002
- Scopus ID
- 2-s2.0-0015275060
- Other Identifier
- 991019231728104721