Journal article
Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain
The Journal of neuroscience, v 30(41), pp 13597-13608
13 Oct 2010
PMID: 20943901
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Astrocytes are an essential component of the CNS, and recent evidence points to an increasing diversity of their functions. Identifying molecular pathways that mediate distinct astrocyte functions, is key to understanding how the nervous system operates in the intact and pathological states. In this study, we demonstrate that the Hedgehog (Hh) pathway, well known for its roles in the developing CNS, is active in astrocytes of the mature mouse forebrain
in vivo
. Using multiple genetic approaches, we show that regionally distinct subsets of astrocytes receive Hh signaling, indicating a molecular diversity between specific astrocyte populations. Furthermore, we identified neurons as a source of Sonic hedgehog (Shh) in the adult forebrain, suggesting that Shh signaling is involved in neuron–astrocyte communication. Attenuation of Shh signaling in postnatal astrocytes by targeted removal of Smoothened, an obligate Shh coreceptor, resulted in upregulation of GFAP and cellular hypertrophy specifically in astrocyte populations regulated by Shh signaling. Collectively, our findings demonstrate a role for neuron-derived Shh in regulating specific populations of differentiated astrocytes.
Metrics
Details
- Title
- Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain
- Creators
- A. Denise R. Garcia - Memorial Sloan Kettering Cancer CenterRalitsa Petrova - Cornell UniversityLiane Eng - Memorial Sloan Kettering Cancer CenterAlexandra L. Joyner - Memorial Sloan Kettering Cancer Center
- Publication Details
- The Journal of neuroscience, v 30(41), pp 13597-13608
- Publisher
- Society for Neuroscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000282874600007
- Scopus ID
- 2-s2.0-77958065240
- Other Identifier
- 991020099921404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences