Journal article
Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus
eLife, v 11
07 Nov 2022
PMID: 36342840
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen required for GABAergic interneuron migration into visual thalamus. However, how retinal axons induce thalamic astrocytes to generate
and influence interneuron migration remains unknown. Here, we demonstrate that impairing RGC activity had little impact on interneuron recruitment into mouse visual thalamus. Instead, our data show that retinal-derived sonic hedgehog (SHH) is essential for interneuron recruitment. Specifically, we show that thalamus-projecting RGCs express SHH and thalamic astrocytes generate downstream components of SHH signaling. Deletion of RGC-derived SHH leads to a significant decrease in
expression, as well as in the percentage of interneurons recruited into visual thalamus. Overall, our findings identify a morphogen-dependent neuron-astrocyte signaling mechanism essential for the migration of thalamic interneurons.
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Details
- Title
- Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus
- Creators
- Rachana Deven Somaiya - Virginia TechKatelyn Stebbins - Virginia TechEllen C Gingrich - Drexel UniversityHehuang Xie - Virginia TechJohn N Campbell - University of VirginiaA Denise R Garcia - Drexel UniversityMichael A Fox - Virginia Tech
- Publication Details
- eLife, v 11
- Publisher
- eLife
- Grant note
- R01 NS096100 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000882453000001
- Scopus ID
- 2-s2.0-85141892229
- Other Identifier
- 991020099921804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology