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Journal article
Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization
eLife, v 8
13 Jun 2019
PMID: 31194676
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Astrocytes have emerged as integral partners with neurons in regulating synapse formation and function, but the mechanisms that mediate these interactions are not well understood. Here, we show that Sonic hedgehog (Shh) signaling in mature astrocytes is required for establishing structural organization and remodeling of cortical synapses in a cell type-specific manner. In the postnatal cortex, Shh signaling is active in a subpopulation of mature astrocytes localized primarily in deep cortical layers. Selective disruption of Shh signaling in astrocytes produces a dramatic increase in synapse number specifically on layer V apical dendrites that emerges during adolescence and persists into adulthood. Dynamic turnover of dendritic spines is impaired in mutant mice and is accompanied by an increase in neuronal excitability and a reduction of the glial-specific, inward-rectifying K+ channel Kir4.1. These data identify a critical role for Shh signaling in astrocyte-mediated modulation of neuronal activity required for sculpting synapses.
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Details
- Title
- Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization
- Creators
- Steven A. Hill - Drexel UniversityAndrew S. Blaeser - Drexel UniversityAustin A. Coley - Drexel UniversityYajun Xie - Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USAKatherine A. Shepard - Drexel UniversityCorey C. Harwell - Harvard UniversityWen-Jun Gao - Drexel UniversityA. Denise R. Garcia - Drexel University
- Publication Details
- eLife, v 8
- Publisher
- Elife Sciences Publications Ltd
- Number of pages
- 23
- Grant note
- Louis Perry Jones Postdoctoral Fellowship R01MH085666 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) 1R01NS096100; F99NS105185; K01NS089720; R01NS102228 / National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Genise Goldenson Junior Faculty Award Pennsylvania Department of Health CURE 5R21MH110724; R01MH085666; 7K01MH097957 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Alice and Joseph Brooks Fund Postdoctoral Fellowship R01NS102228 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Neurobiology and Anatomy
- Web of Science ID
- WOS:000475599500001
- Scopus ID
- 2-s2.0-85069890363
- Other Identifier
- 991019168908604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology