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Journal article
Sonic hedgehog signaling in astrocytes
Cellular and molecular life sciences : CMLS, v 78(4), pp 1393-1403
Feb 2021
PMID: 33079226
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Astrocytes are complex cells that perform a broad array of essential functions in the healthy and injured nervous system. The recognition that these cells are integral components of various processes, including synapse formation, modulation of synaptic activity, and response to injury, underscores the need to identify the molecular signaling programs orchestrating these diverse functional properties. Emerging studies have identified the Sonic hedgehog (Shh) signaling pathway as an essential regulator of the molecular identity and functional properties of astrocytes. Well established as a powerful regulator of diverse neurodevelopmental processes in the embryonic nervous system, its functional significance in astrocytes is only beginning to be revealed. Notably, Shh signaling is active only in discrete subpopulations of astrocytes distributed throughout the brain, a feature that has potential to yield novel insights into functional specialization of astrocytes. Here, we discuss Shh signaling and emerging data that point to essential roles for this pleiotropic signaling pathway in regulating various functional properties of astrocytes in the healthy and injured brain.
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Details
- Title
- Sonic hedgehog signaling in astrocytes
- Creators
- Steven A. Hill - Drexel UniversityMarissa Fu - Drexel UniversityA. Denise R. Garcia - Drexel University
- Publication Details
- Cellular and molecular life sciences : CMLS, v 78(4), pp 1393-1403
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000580409300002
- Scopus ID
- 2-s2.0-85092782058
- Other Identifier
- 991019168671304721
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- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology