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Journal article
Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation
BIO Integration, v 2(1), pp 29-36
06 Apr 2021
Abstract
Ultrasound combined with microbubble-mediated sonoporation has been applied to enhance drug or gene intracellular delivery. Sonoporation leads to the formation of openings in the cell membrane, triggered by ultrasound-mediated oscillations and destruction of microbubbles. Multiple mechanisms
are involved in the occurrence of sonoporation, including ultrasonic parameters, microbubbles size, and the distance of microbubbles to cells. Recent advances are beginning to extend applications through the assistance of contrast agents, which allow ultrasound to connect directly to cellular
functions such as gene expression, cellular apoptosis, differentiation, and even epigenetic reprogramming. In this review, we summarize the current state of the art concerning microbubble-cell interactions and sonoporation effects leading to cellular functions.
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25 citations in Scopus
Details
- Title
- Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation
- Creators
- Yue Li - First Affiliated Hospital of University of South ChinaZhiyi Chen - First Affiliated Hospital of University of South ChinaShuping Ge - St. Christopher's Hospital for ChildrenZhiwei Chen - Civil, Architectural, and Environmental Engineering
- Publication Details
- BIO Integration, v 2(1), pp 29-36
- Publisher
- Compuscript
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; Civil, Architectural, and Environmental Engineering
- Scopus ID
- 2-s2.0-85111473634
- Other Identifier
- 991019173576204721