Journal article
Sordarin, an antifungal agent with a unique mode of action
Beilstein journal of organic chemistry, v 4(1), pp 31-31
05 Sep 2008
PMID: 18941619
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including a norbornene system, inhibits protein synthesis in fungi by stabilizing the ribosome/EF2 complex. This mode of action is in contrast to typical antifungals, which target the cell membrane. This unusual bioactivity makes sordarin a promising candidate for the development of new fungicidal agents, and provided the motivation for extensive research. Three total syntheses (by the Kato, Mander and Narasaka groups), modifications of the glycosyl unit, and changes to the diterpene core (Cuevas and Ciufolini models) will also be discussed in this review.
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Details
- Title
- Sordarin, an antifungal agent with a unique mode of action
- Creators
- Huan Liang - University of British Columbia
- Publication Details
- Beilstein journal of organic chemistry, v 4(1), pp 31-31
- Publisher
- Beilstein-Institut
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000259705400001
- Scopus ID
- 2-s2.0-64349088862
- Other Identifier
- 991019320612704721
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- Web of Science research areas
- Chemistry, Organic