Journal article
Spatial Guidance of Cell Asymmetry: Septin GTPases Show the Way
Traffic (Copenhagen, Denmark), v 13(2), pp 195-203
Feb 2012
PMID: 21883761
Abstract
Eukaryotic cells develop asymmetric shapes suited for specific physiological functions. Morphogenesis of polarized domains and structures requires the amplification of molecular asymmetries by scaffold proteins and regulatory feedback loops. Small monomeric GTPases signal polarity, but how their downstream effectors and targets are spatially coordinated to break cell symmetry is poorly understood. Septins comprise a novel family of GTPases that polymerize into nonpolar filamentous structures that scaffold and restrict protein localization. Recent studies show that septins demarcate distinct plasma membrane domains and cytoskeletal tracks, enabling the formation of intracellular asymmetries. Here, we review these findings and discuss emerging mechanisms by which septins promote cell asymmetry in fungi and animals.
Metrics
Details
- Title
- Spatial Guidance of Cell Asymmetry: Septin GTPases Show the Way
- Creators
- Elias T Spiliotis - Department of Biology, Drexel University, Philadelphia, PA 19104, USAAmy S Gladfelter - Department of Biological Science, Dartmouth College, Hanover, NH 03755, USA
- Publication Details
- Traffic (Copenhagen, Denmark), v 13(2), pp 195-203
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000299161900002
- Scopus ID
- 2-s2.0-84855950538
- Other Identifier
- 991014877770604721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology