Journal article
Spatial control of exocytosis
Current opinion in cell biology, Vol.15(4), pp.430-437
Aug 2003
PMCID: PMC3368606
PMID: 12892783
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During many key biological processes, exocytosis is confined to distinct regions of the plasma membrane. Spatial control of exocytosis correlates with altered membrane skeleton dynamics and assembly of local membrane microdomains. These domains act as local stages for the assembly and the regulation of molecular complexes (targeting patches) that mediate vesicle-membrane fusion. Furthermore, local activation of signaling pathways reinforces formation of these patches and might effect global repositioning of the secretory pathway toward sites of localized exocytosis.
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Details
- Title
- Spatial control of exocytosis
- Creators
- Elias T Spiliotis - Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5435, USAW James Nelson
- Publication Details
- Current opinion in cell biology, Vol.15(4), pp.430-437
- Publisher
- Elsevier; England
- Grant note
- R01 GM035527 / NIGMS NIH HHS R37 GM035527 / NIGMS NIH HHS GM35527 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Identifiers
- 991014877928604721
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- Cell Biology