Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Spatial control of membrane traffic in neuronal dendrites
Molecular and cellular neurosciences, v 105, pp 103492-103492
Jun 2020
PMID: 32294508
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuronal dendrites are highly branched and specialized compartments with distinct structures and secretory organelles (e.g., spines, Golgi outposts), and a unique cytoskeletal organization that includes microtubules of mixed polarity. Dendritic membranes are enriched with proteins, which specialize in the formation and function of the post-synaptic membrane of the neuronal synapse. How these proteins partition preferentially in dendrites, and how they traffic in a manner that is spatiotemporally accurate and regulated by synaptic activity are long-standing questions of neuronal cell biology. Recent studies have shed new insights into the spatial control of dendritic membrane traffic, revealing new classes of proteins (e.g., septins) and cytoskeleton-based mechanisms with dendrite-specific functions. Here, we review these advances by revisiting the fundamental mechanisms that control membrane traffic at the levels of protein sorting and motor-driven transport on microtubules and actin filaments. Overall, dendrites possess unique mechanisms for the spatial control of membrane traffic, which might have specialized and co-evolved with their highly arborized morphology.
Metrics
Details
- Title
- Spatial control of membrane traffic in neuronal dendrites
- Creators
- Megan R Radler - Drexel UniversityAyana Suber - Drexel UniversityElias T Spiliotis - Drexel University
- Publication Details
- Molecular and cellular neurosciences, v 105, pp 103492-103492
- Publisher
- Elsevier
- Grant note
- R01 GM097664 / NIGMS NIH HHS R25 GM086262 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000540195100010
- Scopus ID
- 2-s2.0-85083329124
- Other Identifier
- 991019168360104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences