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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Spatial regulation of microtubule-dependent transport by septin GTPases
Trends in cell biology, v 31(12), pp 979-993
Dec 2021
PMID: 34253430
Abstract
The intracellular long-range transport of membrane vesicles and organelles is mediated by microtubule motors (kinesins, dynein) which move cargo with spatiotemporal accuracy and efficiency. How motors navigate the microtubule network and coordinate their activity on membrane cargo are fundamental but poorly understood questions. New studies show that microtubule-dependent membrane traffic is spatially controlled by septins - a unique family of multimerizing GTPases that associate with microtubules and membrane organelles. We review how septins selectively regulate motor interactions with microtubules and membrane cargo. We posit that septins provide a novel traffic code that specifies the movement and directionality of select motor-cargo complexes on distinct microtubule tracks.
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Details
- Title
- Spatial regulation of microtubule-dependent transport by septin GTPases
- Creators
- Elias T Spiliotis - Drexel UniversityIlona A Kesisova - Drexel University
- Publication Details
- Trends in cell biology, v 31(12), pp 979-993
- Publisher
- Elsevier
- Grant note
- R01 GM097664 / NIGMS NIH HHS R35 GM136337 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000719112900004
- Scopus ID
- 2-s2.0-85110333795
- Other Identifier
- 991019169544804721
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- Web of Science research areas
- Cell Biology