Journal article
Spatiotemporal gating of sensory inputs in thalamus during quiescent and activated states
The Journal of neuroscience, v 25(47), pp 10990-11002
23 Nov 2005
PMID: 16306412
Abstract
The main role of the thalamus is to relay sensory inputs to the neocortex according to the regulations dictated by behavioral state. Hence, changes in behavioral state are likely to transform the temporal and spatial properties of thalamocortical receptive fields. We compared the receptive fields of single cells in the ventroposterior medial thalamus (VPM) of urethane-anesthetized rats during quiescent states and during aroused (activated) states. During quiescent states, VPM cells respond to stimulation of a principal whisker (PW) and may respond modestly to one or a few adjacent whiskers (AWs). During either generalized forebrain activation or selective thalamic activation caused by carbachol infusion in the VPM, the responses to AWs enhance so that VPM receptive fields become much larger. Such enlargement is not observed at the level of the principal trigeminal nucleus, indicating that it originates within the thalamus. Interestingly, despite the increase in AW responses during activation, simultaneous deflection of the PW and AWs produced VPM responses that resembled the PW response, as if the AWs were not stimulated. This nonlinear summation of sensory responses was present during both quiescent and activated states. In conclusion, the thalamus suppresses the excitatory surround (AWs) of the receptive field during quiescent states and enlarges this surround during arousal. But, thalamocortical cells represent only the center (PW) of the receptive field when the center (PW) and surround (AWs) are stimulated simultaneously.
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Details
- Title
- Spatiotemporal gating of sensory inputs in thalamus during quiescent and activated states
- Creators
- Juan R Aguilar - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USAManuel A Castro-Alamancos
- Publication Details
- The Journal of neuroscience, v 25(47), pp 10990-11002
- Publisher
- Society for Neuroscience; United States
- Grant note
- R01 NS046305 / NINDS NIH HHS R01 NS046305-04 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000233460400020
- Scopus ID
- 2-s2.0-28044471998
- Other Identifier
- 991014878208704721
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- Web of Science research areas
- Neurosciences