Journal article
Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression
Journal of neuroimmunology, v 157(1)
2004
PMID: 15579278
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Basal and activated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activity, and in return, viral replication is partly dependent on interactions of the G/C box array with the Sp family of transcription factors. Analysis of LTR Sp binding site sequence variants revealed a C-to-T change at position 5 within Sp site III that increased in frequency and a 5T mutation within Sp site II, which decreased in frequency during the course of HIV disease. These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease.
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Details
- Title
- Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression
- Creators
- Michael R Nonnemacher - Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USABryan P Irish - Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USAYujie Liu - Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USADavid Mauger - Department of Health and Evaluation Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USABrian Wigdahl - Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA
- Publication Details
- Journal of neuroimmunology, v 157(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000225869400006
- Scopus ID
- 2-s2.0-9644266837
- Other Identifier
- 991014878206604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences