Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions
Frontiers in physiology, v 9, pp 784-784
25 Jun 2018
PMID: 29988534
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Systematic research on the physiological and anatomical characteristics of spinal cord interneurons along with their functional output has evolved for more than one century. Despite significant progress in our understanding of these networks and their role in generating and modulating movement, it has remained a challenge to elucidate the properties of the locomotor rhythm across species. Neurophysiological experimental evidence indicates similarities in the function of interneurons mediating afferent information regarding muscle stretch and loading, being affected by motor axon collaterals and those mediating presynaptic inhibition in animals and humans when their function is assessed at rest. However, significantly different muscle activation profiles are observed during locomotion across species. This difference may potentially be driven by a modified distribution of muscle afferents at multiple segmental levels in humans, resulting in an altered interaction between different classes of spinal interneurons. Further, different classes of spinal interneurons are likely activated or silent to some extent simultaneously in all species. Regardless of these limitations, continuous efforts on the function of spinal interneuronal circuits during mammalian locomotion will assist in delineating the neural mechanisms underlying locomotor control, and help develop novel targeted rehabilitation strategies in cases of impaired bipedal gait in humans. These rehabilitation strategies will include activity-based therapies and targeted neuromodulation of spinal interneuronal circuits via repetitive stimulation delivered to the brain and/or spinal cord.
Metrics
Details
- Title
- Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions
- Creators
- Marie-Pascale Cote - Drexel UniversityLynda M. Murray - City University of New YorkMaria Knikou - City University of New York
- Publication Details
- Frontiers in physiology, v 9, pp 784-784
- Publisher
- Frontiers Media Sa
- Number of pages
- 27
- Grant note
- R01NS083666 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) RO1 NS083666 / National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 316299; 339705 / Craig H. Neilsen Foundation C32095GG; C32248GG; C33276GG / New York State Department of Health - Spinal Cord Injury Research Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000436159600001
- Scopus ID
- 2-s2.0-85048960163
- Other Identifier
- 991019168862204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physiology