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Journal article
Spinal Cord Injury Immediately Changes the State of the Brain
The Journal of neuroscience, v 30(22), pp 7528-7537
02 Jun 2010
PMID: 20519527
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury can produce extensive long-term reorganization of the cerebral cortex. Little is known, however, about the sequence of cortical events starting immediately after the lesion. Here we show that a complete thoracic transection of the spinal cord produces immediate functional reorganization in the primary somatosensory cortex of anesthetized rats. Besides the obvious loss of cortical responses to hindpaw stimuli (below the level of the lesion), cortical responses evoked by forepaw stimuli (above the level of the lesion) markedly increase. Importantly, these increased responses correlate with a slower and overall more silent cortical spontaneous activity, representing a switch to a network state of slow-wave activity similar to that observed during slow-wave sleep. The same immediate cortical changes are observed after reversible pharmacological block of spinal cord conduction, but not after sham. We conclude that the deafferentation due to spinal cord injury can immediately (within minutes) change the state of large cortical networks, and that this state change plays a critical role in the early cortical reorganization after spinal cord injury.
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Details
- Title
- Spinal Cord Injury Immediately Changes the State of the Brain
- Creators
- Juan Aguilar - Servicio de Salud de Castilla La ManchaDesire Humanes-Valera - Hosp Nacl Paraplejicos, Serv Salud Castilla La Mancha, Toledo 45071, SpainElena Alonso-Calvino - Hosp Nacl Paraplejicos, Serv Salud Castilla La Mancha, Toledo 45071, SpainJosue G. Yague - Hosp Nacl Paraplejicos, Serv Salud Castilla La Mancha, Toledo 45071, SpainKaren A. Moxon - Drexel UniversityAntonio Oliviero - Hosp Nacl Paraplejicos, Serv Salud Castilla La Mancha, Toledo 45071, SpainGuglielmo Foffani - Hosp Nacl Paraplejicos, Serv Salud Castilla La Mancha, Toledo 45071, Spain
- Publication Details
- The Journal of neuroscience, v 30(22), pp 7528-7537
- Publisher
- Soc Neuroscience
- Number of pages
- 10
- Grant note
- R01 NS057419 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS057419 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Fundacion para la Investigacion Sanitaria en Castilla-La Mancha PI08/1852; PI08/1810 / Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III; Instituto de Salud Carlos III
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000278288200010
- Scopus ID
- 2-s2.0-77953225603
- Other Identifier
- 991019168913504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences