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Journal article
Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways
International journal of molecular sciences, v 22(5), p2667
01 Mar 2021
PMID: 33800863
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ability to sense and move within an environment are complex functions necessary for the survival of nearly all species. The spinal cord is both the initial entry site for peripheral information and the final output site for motor response, placing spinal circuits as paramount in mediating sensory responses and coordinating movement. This is partly accomplished through the activation of complex spinal microcircuits that gate afferent signals to filter extraneous stimuli from various sensory modalities and determine which signals are transmitted to higher order structures in the CNS and to spinal motor pathways. A mechanistic understanding of how inhibitory interneurons are organized and employed within the spinal cord will provide potential access points for therapeutics targeting inhibitory deficits underlying various pathologies including sensory and movement disorders. Recent studies using transgenic manipulations, neurochemical profiling, and single-cell transcriptomics have identified distinct populations of inhibitory interneurons which express an array of genetic and/or neurochemical markers that constitute functional microcircuits. In this review, we provide an overview of identified neural components that make up inhibitory microcircuits within the dorsal and ventral spinal cord and highlight the importance of inhibitory control of sensorimotor pathways at the spinal level.
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Details
- Title
- Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways
- Creators
- Nicholas J. Stachowski - Drexel UniversityKimberly J. Dougherty - Drexel University
- Publication Details
- International journal of molecular sciences, v 22(5), p2667
- Publisher
- Mdpi
- Number of pages
- 17
- Grant note
- R01 NS095366; R01 NS104194; R21 NS118226 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000628280700001
- Scopus ID
- 2-s2.0-85101998415
- Other Identifier
- 991019169522404721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary