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Journal article
Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease
The Journal of neuroscience, v 41(5), pp 845-854
03 Feb 2021
PMID: 33472820
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.
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Details
- Title
- Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease
- Creators
- Lyandysha Zholudeva - Gladstone InstitutesVictoria E. Abraira - Rutgers, The State University of New JerseyKajana Satkunendrarajah - Medical College of WisconsinTodd C. McDevitt - Gladstone InstitutesMartyn D. Goulding - Salk Institute for Biological StudiesDavid S. K. Magnuson - University of LouisvilleMichael A. Lane - Drexel University
- Publication Details
- The Journal of neuroscience, v 41(5), pp 845-854
- Publisher
- Soc Neuroscience
- Number of pages
- 10
- Grant note
- 649984; 465068 / Craig H. Neilsen Roddenberry Foundation Pew Charitable Trust Wings for Life Spinal Cord Research Foundation Whitehall Foundation Frederick W. and Joanne J. Mitchell Chair in Molecular Biology NS111643; NS112959; R01 NS089324; R01 NS104291 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA New Jersey Commission on Spinal Cord Research Lisa Dean Moseley Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000616763400005
- Scopus ID
- 2-s2.0-85101994444
- Other Identifier
- 991019168681304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences