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Journal article
Spinal Shox2 interneuron interconnectivity related to function and development
eLife, v 7
31 Dec 2018
PMID: 30596374
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuronal networks generating hindlimb locomotion are located in the spinal cord. The mechanisms underlying spinal rhythmogenesis are unknown but network activity and interconnectivity of excitatory interneurons likely play prominent roles. Here, we investigate interconnectivity within the Shox2 interneuron population, a subset of which has been suggested to be involved in locomotor rhythm generation, using paired recordings in isolated spinal cords or slices from transgenic mice. Sparse unidirectional connections consistent with chemical synaptic transmission and prominent bidirectional connections mediated by electrical synapses were present within distinct subsets of Shox2 interneurons. Moreover, bidirectional electrical connections were preferentially found between functionally-related Shox2 interneurons. Though prevalent in neonatal mice, electrical coupling began to decline in incidence and strength in mice ~ 3 weeks of age. Overall, our data suggest that gap junctional coupling promotes synchronization of Shox2 interneurons, and may be implicated in locomotor rhythmicity in developing mice.
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Details
- Title
- Spinal Shox2 interneuron interconnectivity related to function and development
- Creators
- Ngoc T Ha - Drexel UniversityKimberly J Dougherty - Drexel University
- Publication Details
- eLife, v 7
- Publisher
- eLife
- Grant note
- R01 NS095366 / NINDS NIH HHS R01 NS095366 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000455567000001
- Scopus ID
- 2-s2.0-85060057865
- Other Identifier
- 991019168600004721
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