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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Spinal circuitry and respiratory recovery following spinal cord injury
Respiratory physiology & neurobiology, v 169(2)
30 Nov 2009
PMID: 19698805
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Numerous studies have demonstrated anatomical and functional neuroplasticity following spinal cord injury. One of the more notable examples is return of ipsilateral phrenic motoneuron and diaphragm activity which can be induced under terminal neurophysiological conditions after high cervical hemisection in the rat. More recently it has been shown that a protracted, spontaneous recovery also occurs in this model. While a candidate neural substrate has been identified for the former, the neuroanatomical basis underlying spontaneous recovery has not been explored. Demonstrations of spinal respiratory interneurons in other species suggest such cells may play a role; however, the presence of interneurons in the adult rat phrenic circuit - the primary animal model of respiratory plasticity - has not been extensively investigated. Emerging neuroanatomical and electrophysiological results raise the possibility of a more complex neural network underlying spontaneous recovery of phrenic function and compensatory respiratory neuroplasticity after C2 hemisection than has been previously considered. (C) 2009 Elsevier B.V. All rights reserved.
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Details
- Title
- Spinal circuitry and respiratory recovery following spinal cord injury
- Creators
- Michael A. Lane - McKnight Brain InstituteKun-Ze Lee - McKnight Brain InstituteDavid D. Fuller - McKnight Brain InstitutePaul J. Reier - McKnight Brain Institute
- Publication Details
- Respiratory physiology & neurobiology, v 169(2)
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Craig H. Neilsen Foundation Anne and Oscar Lackner Chair in Medicine R01NS054025 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) University of Florida R01HD052682 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) NIH NS054025; NIH HD052682; NIH 1R01HD052682-01A1 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000272225400006
- Scopus ID
- 2-s2.0-72049112041
- Other Identifier
- 991019299102104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Physiology
- Respiratory System