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Journal article
Spinal direct current stimulation modulates the activity of gracile nucleus and primary somatosensory cortex in anaesthetized rats
The Journal of physiology, v 589(20), pp 4981-4996
15 Oct 2011
PMCID: PMC3224887
PMID: 21825031
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Afferent somatosensory activity from the spinal cord has a profound impact on the activity of the brain. Here we investigated the effects of spinal stimulation using direct current, delivered at the thoracic level, on the spontaneous activity and on the somatosensory evoked potentials of the gracile nucleus, which is the main entry point for hindpaw somatosensory signals reaching the brain from the dorsal columns, and of the primary somatosensory cortex in anaesthetized rats. Anodal spinal direct current stimulation (sDCS) increased the spontaneous activity and decreased the amplitude of evoked responses in the gracile nucleus, whereas cathodal sDCS produced the opposite effects. At the level of the primary somatosensory cortex, the changes in spontaneous activity induced by sDCS were consistent with the effects observed in the gracile nucleus, but the changes in cortical evoked responses were more variable and state dependent. Therefore, sDCS can modulate in a polarity-specific manner the supraspinal activity of the somatosensory system, offering a versatile bottom-up neuromodulation technique that could potentially be useful in a number of clinical applications.
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Details
- Title
- Spinal direct current stimulation modulates the activity of gracile nucleus and primary somatosensory cortex in anaesthetized rats
- Creators
- J. Aguilar - Hospital Nacional de ParapléjicosF. Pulecchi - Hospital Nacional de ParapléjicosR. Dilena - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoA. Oliviero - Hospital Nacional de ParapléjicosA. Priori - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoG. Foffani - Drexel University
- Publication Details
- The Journal of physiology, v 589(20), pp 4981-4996
- Publisher
- Wiley
- Number of pages
- 16
- Grant note
- FEDER; European Commission FISCAM (Gobierno de Castilla-La Mancha) PI08/1852 PI08/1810 / Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (Spain); Instituto de Salud Carlos III
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000296004900015
- Scopus ID
- 2-s2.0-80054101345
- Other Identifier
- 991019353727404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Physiology