Journal article
Spinal neurons mediate return of substance P following deafferentation of cat spinal cord
Brain research, v 230(1), pp 263-281
28 Dec 1981
PMID: 6172182
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Deafferentation of the cat dorsal horn by complete unilateral lumbosacral dorsal rhizotomy produces a loss and subsequent partial recovery of substance P (SP) immunoreactivity as visualized by the peroxidase-antiperoxidase technique 38. The present experiments aimed to determine whether this return of SP represents a generalized response of all fiber systems afferent to the denervated segments or a more selective response of a specific spinal system. Although a contribution from other sources cannot be excluded by this qualitative immunocytochemical technique, several observations indicate that the return of SP staining depends on interneurons which contain SP immunoreactivity: (1) the amount of SP staining in the chronically deafferented dorsal horn deprived of extrinsic fiber systems is comparable to that seen after deafferentation alone; (2) SP-containing neurons are present within the lumbar segments; and (3) destruction of lumbar neurons by the intraspinal injection of kainic acid abolishes SP staining from the chronically deafferented dorsal horn. From these observations it would appear that the anatomical plasticity of SP-containing fibers in the deafferented dorsal horn is due to the response of a particular system rather than to a generalized response of all systems which terminate there.
Metrics
Details
- Title
- Spinal neurons mediate return of substance P following deafferentation of cat spinal cord
- Creators
- A. Tessler - Drexel University, Medical College of Pennsylvania (1970-1993)B.T. Himes - Drexel University, Medical College of Pennsylvania (1970-1993)R. Artymyshyn - Drexel University, Medical College of Pennsylvania (1970-1993)M. Murray - Drexel University, Medical College of Pennsylvania (1970-1993)M.E. Goldberger - Drexel University, Medical College of Pennsylvania (1970-1993)
- Publication Details
- Brain research, v 230(1), pp 263-281
- Publisher
- Elsevier
- Number of pages
- 19
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1981MW31800019
- Scopus ID
- 2-s2.0-0019783078
- Other Identifier
- 991019184195504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences