Journal article
Spontaneous alternation behavior: An animal model for obsessive-compulsive disorder?
Pharmacology, biochemistry and behavior, v 40(2), pp 311-315
1991
PMID: 1839567
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study entailed the adoption of a well-established behavioral paradigm, spontaneous alternation, as a possible animal model for some of the symptoms observed in obsessive-compulsive disorder (OCD) in humans. Food-deprived rats were run in a T-maze in which both a black and a white goal box were equally baited with a small amount of chocolate milk. Each rat was given 7 trials every other day during which it was placed in the start box and allowed to make a choice. The mean number of choices until an alternation occurred was recorded. After a stable baseline of spontaneous alternation was achieved the effects of manipulating the serotonergic system were tested. Both the nonselective 5-HT agonist 5-MeODMT (1.25 mg/kg) and the more selective 5-HT
1A agonist 8-OH-DPAT (2 mg/kg) disrupted spontaneous alternation. A course of chronic treatment (2 × 5 mg/kg for 21 days) with the selective 5-HT uptake blocking agent fluoxetine had a protective effect on the 5-MeODMT-induced disruption of spontaneous alternation behavior. Serotonergic manipulations of spontaneous alternation may be a simple animal model for the perseverative symptoms or indecisiveness seen in people diagnosed with OCD.
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Details
- Title
- Spontaneous alternation behavior: An animal model for obsessive-compulsive disorder?
- Creators
- Elna Yadin - Drexel UniversityEitan Friedman - Drexel UniversityWagner H. Bridger - Drexel University
- Publication Details
- Pharmacology, biochemistry and behavior, v 40(2), pp 311-315
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1991GQ88200021
- Scopus ID
- 2-s2.0-0026355203
- Other Identifier
- 991019184197604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy