Journal article
Spontaneous clearance of high-titer serum HBV DNA and risk of hepatocellular carcinoma in a Chinese population
Cancer causes & control, v 14(10), pp 995-1000
Dec 2003
PMID: 14750539
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic hepatitis B virus (HBV) carriers with high-titer viremia (>105 virions/ml) are at increased risk for hepatocellular carcinoma (HCC). The aim of this study was to determine the relationship between clearance of high-titer viremia and subsequent risk of HCC. The study population was a prospective cohort of 114 adults from Haimen City, China, all HBV DNA(+) at study entry and followed for 797.8 person-years in total. During follow-up, 54 (47.4%) subjects spontaneously cleared high-titer viremia at least once. Of these, 27 were considered to have undergone stable seroconversion, 16 were considered unstable (12 reversions to HBV DNA positivity and 4 multiple clearances), and 11 did not have sufficient follow-up to determine stability. Of the 114 persons, 26 (22.8%) died during follow-up, 21 (18.4%) from HCC. Using Cox proportional hazards models, the RR of HCC death associated with seroconversion was 2.8 (95% CI = 1.1–7.4), controlling for age, sex, family HCC history, history of acute hepatitis, alcohol use and cigarette smoking. In conclusion, fluctuations of high-titer viremia may indicate increased hepatocellular damage and at least short-term increases in HCC risk. Long-term longitudinal studies are needed to clarify this relationship and its potential usefulness as a prognostic marker in chronic HBV infection.
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Details
- Title
- Spontaneous clearance of high-titer serum HBV DNA and risk of hepatocellular carcinoma in a Chinese population
- Creators
- Rebecca Harris - Division of Population Science Fox Chase Cancer Center Philadelphia PA USAGang Chen - Division of Population Science Fox Chase Cancer Center Philadelphia PA USAWen Lin - Haimen City Centers for Disease Control Haimen City PR ChinaFu Shen - Fudan University School of Public Health Shanghai PR ChinaW London - Division of Population Science Fox Chase Cancer Center Philadelphia PA USAAlison Evans - Division of Population Science Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USA
- Publication Details
- Cancer causes & control, v 14(10), pp 995-1000
- Publisher
- Kluwer Academic Publishers; Dordrecht
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000187199400011
- Scopus ID
- 2-s2.0-0345864040
- Other Identifier
- 991014878301204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health