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Journal article
Sprouting of afferent and efferent inputs to pelvic organs after spinal cord injury
Journal of neuropathology and experimental neurology, v 83(1)
22 Dec 2023
PMID: 38102789
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neural plasticity occurs within the central and peripheral nervous systems after spinal cord injury (SCI). Although central alterations have extensively been studied, it is largely unknown whether afferent and efferent fibers in pelvic viscera undergo similar morphological changes. Using a rat spinal cord transection model, we conducted immunohistochemistry to investigate afferent and efferent innervations to the kidney, colon, and bladder. Approximately 3-4 weeks after injury, immunostaining demonstrated that tyrosine hydroxylase (TH)-labeled postganglionic sympathetic fibers and calcitonin gene-related peptide (CGRP)-immunoreactive sensory terminals sprout in the renal pelvis and colon. Morphologically, sprouted afferent or efferent projections showed a disorganized structure. In the bladder, however, denser CGRP-positive primary sensory fibers emerged in rats with SCI, whereas TH-positive sympathetic efferent fibers did not change. Numerous CGRP-positive afferents were observed in the muscle layer and the lamina propria of the bladder following SCI. TH-positive efferent inputs displayed hypertrophy with large diameters, but their innervation patterns were sustained. Collectively, afferent or efferent inputs sprout widely in the pelvic organs after SCI, which may be one of the morphological bases underlying functional adaptation or maladaptation.
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Details
- Title
- Sprouting of afferent and efferent inputs to pelvic organs after spinal cord injury
- Creators
- Shunyi Zhao - Drexel UniversityChuanxi Tang - Xuzhou Medical CollegeJeremy Weinberger - Drexel UniversityDianshuai Gao - Department of Neurobiology and Cell Biology, Key Laboratory of Neurobiology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaShaoping Hou (Corresponding Author) - Drexel University
- Publication Details
- Journal of neuropathology and experimental neurology, v 83(1)
- Publisher
- Oxford University Press
- Grant note
- R01 NS121336 / NINDS NIH HHS R01 NS099076 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001125123900001
- Scopus ID
- 2-s2.0-85181178935
- Other Identifier
- 991021811731204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pathology