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Stability and decline in gross motor function among children and youth with cerebral palsy aged 2 to 21 years
Journal article   Open access   Peer reviewed

Stability and decline in gross motor function among children and youth with cerebral palsy aged 2 to 21 years

Steven E Hanna, Peter L Rosenbaum, Doreen J Bartlett, Robert J Palisano, Stephen D Walter, Lisa Avery and Dianne J Russell
Developmental medicine and child neurology, v 51(4), pp 295-302
Apr 2009
DOI: https://doi.org/10.1111/j.1469-8749.2008.03196.x
PMID: 19391185
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1111/j.1469-8749.2008.03196.xView
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Psychomotor Performance Age Factors Motor Skills - physiology Humans Cerebral Palsy - physiopathology Child, Preschool Infant Male Adolescent Development - physiology Young Adult Cerebral Palsy - complications Models, Biological Adolescent Female Child Development - physiology Motor Skills Disorders - physiopathology Child Longitudinal Studies Motor Skills Disorders - etiology Cohort Studies
This paper reports the construction of gross motor development curves for children and youth with cerebral palsy (CP) in order to assess whether function is lost during adolescence. We followed children previously enrolled in a prospective longitudinal cohort study for an additional 4 years, as they entered adolescence and young adulthood. The resulting longitudinal dataset comprised 3455 observations of 657 children with CP (369 males, 288 females), assessed up to 10 times, at ages ranging from 16 months to 21 years. Motor function was assessed using the 66-item Gross Motor Function Measure (GMFM-66). Participants were classified using the Gross Motor Function Classification System (GMFCS). We assessed the loss of function in adolescence by contrasting a model of function that assumes no loss with a model that allows for a peak and subsequent decline. We found no evidence of functional decline, on average, for children in GMFCS Levels I and II. However, in Levels III, IV, and V, average GMFM-66 was estimated to peak at ages 7 years 11 months, 6 years 11 months, and 6 years 11 months respectively, before declining by 4.7, 7.8, and 6.4 GMFM-66 points, in Levels III, IV, and V respectively, as these adolescents became young adults. We show that these declines are clinically significant.

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Clinical Neurology
Pediatrics
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