Journal article
Stabilizing electrode-host interfaces: a tissue engineering approach
Journal of rehabilitation research and development, v 38(6), pp 627-632
Nov 2001
PMID: 11767970
Abstract
The stability of implanted electrodes is a significant problem affecting their long-term use in vivo. Problems include mechanical failure and inflammation at the implantation site. The engineering of bioactive electrode coatings has been investigated for its potential to promote in-growth of neural tissue and reduce sheer at the electrode-host interface. Preliminary results indicate that hydrogel coatings with either collagen I or polylysine-laminin-1 can promote cortical nerve cell attachment and differentiation on silicon substrates. Additionally, slow-release microtubules can also be implanted in these gels to release agents that either provide trophic support to neurons or prevent inflammation locally. When silicon discs are coated with collagen type I, the coating remains stable for 55 days. Further testing is underway, but initial results indicate that tissue-engineering approaches provide useful insights to help address the problem of host-electrode instability in the brain.
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Details
- Title
- Stabilizing electrode-host interfaces: a tissue engineering approach
- Creators
- Y Zhong - Biomaterials, Cell and Tissue Engineering Laboratory, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106-7207, USAX YuR GilbertR V Bellamkonda
- Publication Details
- Journal of rehabilitation research and development, v 38(6), pp 627-632
- Publisher
- United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000172731200006
- Scopus ID
- 2-s2.0-0035706178
- Other Identifier
- 991014878637404721
InCites Highlights
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- Web of Science research areas
- Rehabilitation