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Accepted (AM)CC BY-NC-ND V4.0, Open
Journal article
Standardising definitions for the pre-eclampsia core outcome set: A consensus development study
Pregnancy hypertension, v 21, pp 208-217
Jul 2020
PMID: 32674052
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Using formal consensus development methods, consensus definitions have been developed for the core outcome set for pre-eclampsia.•Consensus definitions were developed specifically for low- and middle-income countries for several core outcomes including stroke, pulmonary oedema, and acute kindey injury.•Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised controlled trials and systematic reviews.
To develop consensus definitions for the core outcome set for pre-eclampsia.
Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group.
Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring.
Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice.
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Details
- Title
- Standardising definitions for the pre-eclampsia core outcome set: A consensus development study
- Creators
- James M.N. Duffy - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United KingdomAlexandra E. Cairns - Nuffield Department of Primary Care Health Sciences University of Oxford Oxford United KingdomLaura A. Magee - King's College LondonPeter von Dadelszen - Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, London, United KingdomJanneke van 't Hooft - Academic Medical CenterChris Gale - Imperial College LondonMark Brown - St George HospitalLucy C. Chappell - King's College LondonWilliam A. Grobman - Northwestern UniversityRay Fitzpatrick - Health Services Research Unit, Nuffield Department of Population Health, University of Oxford Oxford United KingdomS. Ananth Karumanchi - Cedars-Sinai Medical CenterD. Nuala Lucas - London North West Healthcare NHS TrustBen Mol - Women’s Health Care Research Group, Department of Obstetrics and Gynaecology, Monash University, Clayton, AustraliaMichael Stark - University of AdelaideShakila Thangaratinam - Queen Mary University of LondonMathew J. Wilson - University of SheffieldPaula R. Williamson - University of LiverpoolSue Ziebland - Nuffield Department of Primary Care Health Sciences University of Oxford Oxford United KingdomRichard J. McManus - Nuffield Department of Primary Care Health Sciences University of Oxford Oxford United KingdomInternational Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE)Vineet Bhandari - Pediatrics
- Publication Details
- Pregnancy hypertension, v 21, pp 208-217
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000563423900036
- Scopus ID
- 2-s2.0-85087746870
- Other Identifier
- 991019173749804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Peripheral Vascular Disease