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Journal article
Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target
Journal of experimental & clinical cancer research, v 41(1), pp 161-161
02 May 2022
PMID: 35501821
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Stanniocalcin 2 (STC2) is a glycoprotein which is expressed in a broad spectrum of tumour cells and tumour tissues derived from human breast, colorectum, stomach, esophagus, prostate, kidney, liver, bone, ovary, lung and so forth. The expression of STC2 is regulated at both transcriptional and post-transcriptional levels; particularly, STC2 is significantly stimulated under various stress conditions like ER stress, hypoxia and nutrient deprivation. Biologically, STC2 facilitates cells dealing with stress conditions and prevents apoptosis. Importantly, STC2 also promotes the development of acquired resistance to chemo- and radio- therapies. In addition, multiple groups have reported that STC2 overexpression promotes cell proliferation, migration and immune response. Therefore, the overexpression of STC2 is positively correlated with tumour growth, invasion, metastasis and patients' prognosis, highlighting its potential as a biomarker and a therapeutic target. This review focuses on discussing the regulation, biological functions and clinical importance of STC2 in human cancers. Future perspectives in this field will also be discussed.
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Details
- Title
- Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target
- Creators
- Shuo Qie - Tianjin Medical University Cancer Institute and HospitalNianli Sang - Drexel University
- Publication Details
- Journal of experimental & clinical cancer research, v 41(1), pp 161-161
- Publisher
- Springer BMC
- Grant note
- B2102 / 2021 Tianjin Medical University Cancer Institute and Hospital Talent Program and Start-up Grant for Doctors 2021-1-7 / Tianjin Medical University Cancer Institute and Hospital
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Biology
- Web of Science ID
- WOS:000789833500001
- Scopus ID
- 2-s2.0-85129347075
- Other Identifier
- 991019167967804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology