Journal article
Static and Dynamic Cumulative Maximum Intensity Display Mode for Subharmonic Breast Imaging A Comparative Study With Mammographic and Conventional Ultrasound Techniques
Journal of ultrasound in medicine, v 29(8), pp 1177-1185
01 Aug 2010
PMID: 20660451
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. The purpose of this study was to test the efficacy of static and dynamic cumulative maximum intensity (CMI) subharmonic imaging (SHI) in breast ultrasound studies. Methods. Contrast-enhanced SHI was performed in 14 women using a modified LOGIQ 9 scanner (GE Healthcare, Milwaukee, WI) transmitting/receiving at 4.4/2.2 MHz. Following mammography, baseline scans of gray scale ultrasound and power Doppler imaging (PDI) were performed. Contrast-enhanced PDI and gray scale SHI were performed after contrast agent administration. Static CMI-SHI is a composite image summarizing blood flow over multiple frames using the maximum intensity projection technique. The dynamic CMI-SHI mode depicts the gradual inflow pattern of the contrast agent in blood vessels. Both CMI-SHI modes were set up using a new automated sum-absolute-difference-based block-matching algorithm to reduce noise and blurring and compensate for motion artifacts. Evaluation of the imaging modes for detecting breast cancer was done by an experienced radiologist, blinded to histopathologic findings. Sensitivity, specificity, and receiver operating characteristic (ROC) analyses were computed and compared for all ultrasound imaging modes and mammography. Results. Of the 16 lesions, 4 were malignant. The area under the ROC curve (A,) for the diagnosis of breast cancer was 0.64 for gray scale and PDI, 0.67 for contrast-enhanced PDI, 0.76 for mammography, 0.78 for SHI, and 0.75 for static CMI-SHI. For the dynamic CMI-SHI mode, the A, increased to 0.90, and this was significantly better than mammography (P = .03). Conclusions. The new dynamic CMI-SHI mode produced the highest A, for the diagnosis of breast cancer compared to conventional techniques and thus appears to improve diagnosis of breast cancer relative to conventional techniques, albeit based on a limited patient population.
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Details
- Title
- Static and Dynamic Cumulative Maximum Intensity Display Mode for Subharmonic Breast Imaging A Comparative Study With Mammographic and Conventional Ultrasound Techniques
- Creators
- Jaydev K. Dave - Thomas Jefferson UniversityFlemming Forsberg - Thomas Jefferson UniversitySavitha Fernandes - Drexel UniversityCatherine W. Piccoli - S Jersey Radiol Associates, Voorhees, NJ USATraci B. Fox - Thomas Jefferson UniversityDaniel A. MertonLauren M. Leodore - Drexel UniversityAnne L. Hall - GE Healthcare (Netherlands)
- Publication Details
- Journal of ultrasound in medicine, v 29(8), pp 1177-1185
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- DAMD-17-00-1-0464 / US Army Medical Research Material Command; U.S. Army Medical Research & Materiel Command (USAMRMC) GE Healthcare; General Electric
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000280615500004
- Scopus ID
- 2-s2.0-77955626529
- Other Identifier
- 991019350595104721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging