Journal article
Statin-induced immune-mediated necrotizing myopathy with concomitant increase of anti-HMGCR and anti-ACHR antibodies
Rheumatology international, v 44(5), pp 955-959
01 May 2024
PMID: 38461445
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Statin-induced immune-mediated necrotizing myopathy (IMNM) is a rare systemic neuromuscular condition. We present a case of a patient with a severe phenotype of the disease that was found to have an increase in anti-HMGCR and anti-ACHR antibodies. A potential association between these antibodies have not been previously described. A 67-year-old male with hyperlipidemia, who was recently initiated on atorvastatin therapy, presented to the ED with progressive muscle weakness. Within a few days of admission, the patient developed complete flaccid paralysis and respiratory distress requiring intubation. The patient's CK was elevated to 24,000 and there was an increase of anti-HMGCR and anti-ACHR antibodies. Impressions from MRI and thigh biopsy solidified a diagnosis of statin-induced IMNM. The patient was treated with methylprednisolone, IVIG, and rituximab, which provided resolution of symptoms.
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Details
- Title
- Statin-induced immune-mediated necrotizing myopathy with concomitant increase of anti-HMGCR and anti-ACHR antibodies
- Creators
- Razmig Garabet (Corresponding Author) - Drexel UniversitySanjeev Herr - Drexel UniversityNicole Griffin - Kaiser Permanente Walnut Creek Medical CenterKuruganti Reddy - Kaiser Permanente
- Publication Details
- Rheumatology international, v 44(5), pp 955-959
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; General Internal Medicine
- Web of Science ID
- WOS:001179087600001
- Scopus ID
- 2-s2.0-85187112495
- Other Identifier
- 991022202510904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology