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Journal article
Statistical physics and Alzheimer's disease
Physica A, v 249(1-4), pp 460-471
01 Feb 1998
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Abstract
We discuss the possible utility of statistical physics in elucidating some of the puzzling phenomena that seem to occur in the brains of patients affected with Alzheimer's disease. Further, we report three specific results from this approach: (i) The size distribution of senile plaques appears to be log-normal, (ii) We develop a model for growth of senile plaques that is characterized by both aggregation and disaggregation, and (iii) We quantify neuron architecture and find quantitative evidence for the existence of microcolumns positioned at right angles to the known lamina.
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Details
- Title
- Statistical physics and Alzheimer's disease
- Creators
- H Eugene StanleySergey Buldyrev - Boston UniversityLuis Cruz - Boston UniversityTeresa Gomez-Isla - Boston UniversityShlomo Havlin - Bar-Ilan UniversityBradley Hyman - Massachusetts General HospitalRoger Knowles - Boston UniversityBrigita Urbanc - Boston UniversityClaire Wyart - Boston University
- Publication Details
- Physica A, v 249(1-4), pp 460-471
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000072486000066
- Scopus ID
- 2-s2.0-0347145645
- Other Identifier
- 991019296530104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physics, Multidisciplinary