Journal article
Status Toward the Implementation of Precision Dosing in Children
Journal of clinical pharmacology, v 61 Suppl 1(1), pp S36-S51
Jun 2021
PMID: 34185896
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Precision dosing is progressing beyond the conceptual and proof-of-concept stages toward implementation. As the availability of dosing algorithms, tools, and platforms increases, so do the investment in technology services and actual implementation of clinical services offering these solutions to patients. Nowhere is this needed more than in pediatric populations, which are still reliant on adult drug development and bridging strategies to support dosing, often in the absence of actual dose-finding studies in the target pediatric population. Still, there is more work to be done to ensure that proper governance of these services is maintained, and that sustainability of these early implementations is guided by new science as it evolves and meaningful outcome data to confirm that such services deliver on both clinical and economic return on investment. In addition, the field should ensure that all approaches beyond a therapeutic drug monitoring-driven, pharmacokinetic-centric approach should be considered as the tools and services evolve, especially when pediatric-specific pharmacokinetic/pharmacodyamic and pharmacogenetic data are available and shown to be useful to guide dosing. This review evaluates current pediatric precision dosing efforts, highlighting their utility, longevity, and sustainability and assesses the current process for implementing such approaches examining current barriers that stand in the way of broader implementation and the stakeholders that must engage to ensure its ultimate success.
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Details
- Title
- Status Toward the Implementation of Precision Dosing in Children
- Creators
- Jeffrey S Barrett - Critical Path InstituteRyan F Barrett - Drexel UniversityAlexander A Vinks - University of Cincinnati Medical Center
- Publication Details
- Journal of clinical pharmacology, v 61 Suppl 1(1), pp S36-S51
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000667826300006
- Scopus ID
- 2-s2.0-85108847164
- Other Identifier
- 991019168625704721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy