Journal article
Status epilepticus: immunologic and inflammatory mechanisms
Seminars in pediatric neurology, v 21(3)
Sep 2014
PMID: 25510944
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Status epilepticus (SE) can be difficult to treat, particularly if refractory, and lead to significant morbidity and mortality. Prolonged seizures are also a risk factor for the subsequent diagnosis of epilepsy. Activation of the immune system and inflammation are areas of recent interest in the field of epilepsy, and there is growing evidence that these may be involved in the pathogenesis of ongoing SE and subsequent epileptogenesis. We review the current data on this topic in both animal models and human disease. We conclude that there is evidence suggesting a role for immunologic and inflammatory mechanisms in SE. Further research, especially human studies, is necessary to determine whether targeting the immune system would improve control of SE and prevent sequelae such as epileptogenesis.
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Details
- Title
- Status epilepticus: immunologic and inflammatory mechanisms
- Creators
- Chandrabhaga Miskin - St. Christopher's Hospital for ChildrenDaphne M Hasbani - St. Christopher's Hospital for Children
- Publication Details
- Seminars in pediatric neurology, v 21(3)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000346888000005
- Scopus ID
- 2-s2.0-84916936909
- Other Identifier
- 991019168285504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics