Journal article
Stem cells and brain cancer
Experimental cell research, v 306(2), pp 323-329
10 Jun 2005
PMID: 15925587
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
One of the most devastating CNS pathologies is brain cancer. The undifferentiated character of brain tumor cells and recent reports of cancer stem cells prompt questions regarding the involvement of normal stem/progenitor cells in brain tumor biology, their potential contribution to the tumor itself, and whether they are the cause or the consequence of tumor initiation and progression. The cancer stem cell model proposes a clonally derived brain tumor arising from a cancer stem cell. This tumor cell-of-origin originates from a stem/progenitor or more differentiated cell via acquisition of oncogenic mutations that dysregulate or allow reacquisition of self-renewal mechanisms. The tumor cells differentiate unidirectionally from the cancer stem cell in a way parallel to normal development. However, several properties of brain tumors add complexity to this model. For example, the apparent lineage and differentiation status of tumor cells are significantly affected by signaling abnormalities that are causally related to formation of the tumor. In addition, these tumors recruit normal CNS stem and progenitor cells to the tumor mass leading to the possibility of a heterogeneous and polyclonal cell population. It is likely that a complete description of the role of stem cells in brain tumors will be more complex than our current models.
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Details
- Title
- Stem cells and brain cancer
- Creators
- Elena I. Fomchenko - Memorial Sloan Kettering Cancer CenterEric C. Holland - Memorial Sloan Kettering Cancer Center
- Publication Details
- Experimental cell research, v 306(2), pp 323-329
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000229694000004
- Scopus ID
- 2-s2.0-19544378137
- Other Identifier
- 991022004877804721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Oncology