Journal article
Stereotactic Radiosurgery for Intraventricular Metastases: A Multicenter Study
Neurosurgery, v 92(3), pp 565-573
01 Mar 2023
PMID: 36512817
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND:Intraventricular metastases (IVMs) are uncommon, and their optimal management remains debatable.OBJECTIVE:To define the safety and efficacy of stereotactic radiosurgery (SRS) in the treatment of IVMs.METHODS:This retrospective, multicenter study included patients managed with SRS for IVMs. SRS-induced adverse events, local tumor or intracranial progression, and the frequency of new-onset hydrocephalus or leptomeningeal spread were documented. Analyses of variables related to patient neuroimaging or clinical outcomes were also performed.RESULTS:The cohort included 160 patients from 11 centers who underwent SRS for treatment of 1045 intracranial metastases, of which 196 were IVMs. The median survival from SRS was 10 months. Of the 154 patients and 190 IVMs with imaging follow-up, 94 patients (61%) experienced distant intracranial disease progression and 16 IVMs (8.4%) progressed locally. The 12- and 24-month local IVM control rates were 91.4% and 86.1%, respectively. Sixteen (10%) and 27 (17.5%) patients developed hydrocephalus and leptomeningeal dissemination post-SRS, respectively. Adverse radiation effects were documented in 24 patients (15%). Eleven patients (6.9%) died because of intracranial disease progression.CONCLUSION:SRS is an effective treatment option for IVMs, with a local IVM control rate comparable with SRS for parenchymal brain metastases. Leptomeningeal spread and hydrocephalus in patients with IVM occur in a minority of patients, but these patients warrant careful follow-up to detect these changes.
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Details
- Title
- Stereotactic Radiosurgery for Intraventricular Metastases: A Multicenter Study
- Creators
- Georgios Mantziaris - Neurological SurgeryStylianos Pikis - University of VirginiaZhiyuan Xu - University of VirginiaReed Mullen - NYU Langone HealthJuan Alzate - NYU Langone HealthKenneth Bernstein - NYU Langone HealthDouglas Kondziolka - NYU Langone HealthZhishuo Wei - Neurological SurgeryAjay Niranjan - University of PittsburghL. Dade Lunsford - University of PittsburghRoman Liscak - Na Homolce HospitalJaromir May - Na Homolce HospitalCheng-chia Lee - Taipei Veterans General HospitalHuai-che Yang - Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Taipei, TaiwanFrancois-Louis Coupe - Université de SherbrookeDavid Mathieu - Université de SherbrookeKimball Sheehan - University of VirginiaDarrah Sheehan - Neurological SurgeryJoshua D. Palmer - The Ohio State University Wexner Medical CenterHaley K. Perlow - The Ohio State University Wexner Medical CenterSelcuk Peker - Koç UniversityYavuz Samanci - Koç UniversityJennifer Peterson - Jacksonville CollegeDaniel M. Trifiletti - Jacksonville CollegeMatthew J. Shepard - Allegheny Health NetworkShahed Elhamdani - Allegheny Health NetworkRodney E. Wegner - Allegheny Health NetworkHerwin Speckter - Instituto Tecnológico de Santo DomingoWenceslao Hernandez - Instituto Tecnológico de Santo DomingoRonald E. Warnick - Jewish HospitalJason Sheehan - Neurological Surgery
- Publication Details
- Neurosurgery, v 92(3), pp 565-573
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000936650300035
- Scopus ID
- 2-s2.0-85148250220
- Other Identifier
- 991022154811004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery