Journal article
Stereotactic radiosurgery for recurrent high-grade gliomas
Journal of clinical neuroscience, v 135, p111150
01 May 2025
PMID: 40015114
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•High-grade gliomas (WHO Grade III and IV) invariably recur.•Stereotactic Radiosurgery (SRS) may be beneficial in the recurrent treatment setting.•We conducted a retrospective cohort study consisting of 33 patients with rHGGs treated with SRS.•Median overall survival (OS) and progression free survival (PFS) were consistent with previous literature.•MGMT methylation status predicted improved OS.
High-grade gliomas (WHO Grade III and IV) invariably recur. Standardized management in the recurrent setting is ill defined. Stereotactic radiosurgery (SRS) represents a non-invasive treatment modality. Evidence to date is limited and therefore further evaluation of the role of SRS in recurrent high-grade-gliomas (rHGG) is warranted.
We conducted a retrospective cohort study consisting of 33 patients with rHGGs treated with SRS from January 2020 to June 2024. Baseline demographics, radiosurgical parameters, and outcomes/toxicity data were collected. Descriptive statistics were calculated for all continuous variables. Survival analysis was performed using the Kaplan Meier method. Univariate analysis was performed using Cox proportional hazard model. All statistics were performed in GraphPad Prism (V.10).
Thirty-three patients with 44 rHGG lesions underwent Gamma Knife SRS with a median of 5 fractions (range:1–5). Overall local control at 3-,6-, and 12-months was 69.9 %, 45.9 %, and 31.9 % respectively. Distant tumor control at 3-,6-, and 12-months was 71.7 %, 48.2 %, and 42.2 %. Global tumor control was at 3-,6, and 12-months was 69.9 %, 45.9 %, 31.9 % respectively. Median OS from the time of SRS was 7 months (95 % CI: 6.65–17.23). Median PFS from the time of SRS was 5.5 months (95 % CI: 4.79–14.31). MGMT methylated status was associated with improved OS (HR: 0.24 95 % CI: 0.07–0.60, P = 0.01).
SRS affords reasonable local control in the short term for patients with recurrent HGG who are otherwise poor surgical candidates. Local failure is more common than distant failure, albeit global control is critical in increasing PFS. MGMT methylated status is associated with increased overall survival.
Metrics
1 Record Views
Details
- Title
- Stereotactic radiosurgery for recurrent high-grade gliomas
- Creators
- Trent Kite - Allegheny Health NetworkVineetha Yadlapalli - Drexel UniversityJohn Herbst - Allegheny Health NetworkStephen Karlovits - Allegheny Health NetworkRodney E. Wegner - Allegheny Health NetworkMatthew J. Shepard - Allegheny Health Network
- Publication Details
- Journal of clinical neuroscience, v 135, p111150
- Publisher
- Elsevier Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology; Neurosurgery
- Web of Science ID
- WOS:001435144000001
- Scopus ID
- 2-s2.0-85218887668
- Other Identifier
- 991022155292804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences