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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Steroids and injury to the developing brain: net harm or net benefit?
Clinics in perinatology, v 41(1), pp 191-208
Mar 2014
PMID: 24524455
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Deleterious effects result from both glucocorticoid insufficiency and excess glucocorticoid tissue exposure in the developing brain. Accumulating evidence suggests a net benefit of postnatal glucocorticoid therapy when administered shortly after the first week of life to premature infants with early and persistent pulmonary dysfunction, particularly in those with evidence of relative adrenal insufficiency. The decision to treat with steroids should ensure maximum respiratory benefit at the lowest possible neurologic risk, while avoiding serious systemic complications. Ongoing clinical trials must validate this approach.
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Details
- Title
- Steroids and injury to the developing brain: net harm or net benefit?
- Creators
- Shadi N Malaeb - St. Christopher's Hospital for ChildrenBarbara S Stonestreet - Women & Infants Hospital of Rhode Island
- Publication Details
- Clinics in perinatology, v 41(1), pp 191-208
- Publisher
- Elsevier
- Grant note
- R01 HD057100 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000332134900014
- Scopus ID
- 2-s2.0-84893812681
- Other Identifier
- 991019167959104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics